Debaio Li

Debiao Li

Debiao Li

Professor
PhD, Biomedical Engineering, University of Virginia

Northwestern University
2145 Sheridan Road, E310
Evanston, Illinois 60208-3107

Phone:  (312) 926-4245
Fax:  (312) 503-0137
E-mail: d-li2@northwestern.edu

Website(s):  http://www.cardiacmri.nmh.org/


Reseach Interests

Magnetic resonance imaging (MRI) is an emerging technique to evaluate human anatomy and function non-invasively. The goal of our research is to develop new MR imaging methods to detect coronary artery-related heart disease, the No.1 cause of death in the Western world. Our recent research interests include: to develop ultra-fast and real-time MRI techniques to acquire high-resolution images of coronary arteries; to detect the presence and characterize the composition of vascular plaques using MRI; to measure blood flow and blood oxygen level in the heart muscle using MRI; to guide vascular interventional procedures for disease treatments using MRI; to evaluate the utility of MR contrast agents in imaging the anatomy and function of the heart; and MR molecular imaging.

Our research aims to address important clinical questions. New techniques developed by our group have been applied in clinical practice worldwide. We have strong collaborations with our industrial partner, Siemens Medical Solutions, Erlangen, Germany, which have their Cardiovascular MR Research and Development Group (consisting of five senior scientists) stationed at our research facility working with us side by side. This enables us to have fast access to the most advanced hardware and software of MR imaging systems and allows us to implement new techniques on the imaging systems for immediate clinical applications.


Selected Publications

  1. Li D, Carr JC, Shea SM, Zheng J, Deshpande VS, Wielopolski P, Finn JP. Coronary arteries: magnetization-prepared contrast-enhanced, three-dimensional volume-targeted breath-hold MR angiography. Radiology 2001; 219:270-277.
  2. Deshpande VS, Shea SM, Laub G, Simonetti OP, Finn JP, Li D. 3D magnetization-prepared true-FISP: a new technique for imaging coronary arteries. Magn Reson Med 2001; 46:494-502.
  3. Wright KB, Klocke FJ, Deshpande VS, Zheng J, Harris K, Tang R, Finn JP, Li D. Assessment of regional differences in myocardial blood flow using T2-weighted 3D BOLD imaging. Magn Reson Med 2001; 46:573-578.
  4. Larson AC, Simonetti OP, Li D. Coronary MRA with 3D undersampled projection reconstruction TrueFISP. Magn Reson Med 2002; 48:594-601.
  5. Shea SM, Deshpande VS, Chung YC, Li D. 3D TrueFISP imaging of the coronary arteries: improved contrast with T2-preparation. J Magn Reson Imaging 2002; 15:597-602.
  6. Green JD, Omary RA, Finn JP, Chung YC, Tang R, Li YZ, Carr JC, Li D. Passive catheter tracking using MRI: comparison of conventional and magnetization-prepared FLASH. J Magn Reson Imaging 2002; 16:104-109
  7. Omary RA, Green JD, Schirf B, Li Y, Finn JP, Li D. Real-time magnetic resonance imaging-guided coronary catheterization in swine. Circulation, 2003; 107:2656-2659.
  8. Zheng J, Wang J, Nolte M, Li D, Gropler RJ, Woodard PK. Dynamic estimation of myocardial oxygen extraction ratio during dipyridamole stress by MRI: a preliminary study in canines. Magn Reson Med 2004; 51:718-726.
  9. Singh RK, Deshpande VS, Haacke EM, Shea SM, Xu Y, McCarthy RM, Carr JC, Li D. Coronary artery imaging using 3D breath-hold True-FISP with 2D iterative partial Fourier reconstruction. J Magn Reson Imaging 2004; 19:645-649.
  10. Park J, Li D. Feasibility and performance of breath-hold 3D True-FISP coronary MRA using self-calibrating parallel acquisition. Magn Reson Med 2004; 52:7-13.
  11. Fieno DS, Shea SM, Li Y, Harris KR, Finn JP, Li D. Myocardial perfusion imaging based on the blood oxygen level dependent effect using T2-prepared steady state free precession MRI. Circulation 2004; 110:1284-1290.
  12. Green JD, Schirf BE, Omary RA, McCarthy RM, Carr JC, Li D. Projection imaging of the right coronary artery with an intravenous injection of contrast agent. Magn Reson Med 2004; 52:699-703.
  13. Crowe ME, Larson AC, Zhang Q, Carr J, White RD, Li D, Simonetti OP. Automated rectilinear self-gated cardiac cine imaging. Magn Reson Med 2004; 52:782-788.
  14. Shea SM, Schirf BE, Bi X, Tang R, Lu B, Omary RA, Li D. Myocardial perfusion evaluation with T2-prepared gradient echo blood oxygen level dependent imaging at 3 Tesla. Comput Cardiol 2004; 31:145-148.
  15. Park J, Zhang Q, Jellus V, Simonetti O, Li D. Artifacts and noise suppression in GRAPPA imaging using improved k-space coil calibration and optimized variable density sampling. Magn Reson Med 2005; 53:186-193.
  16. Larson AC, Kellman P, Arai A, Hirsch GA, McVeigh E, Li D, Simonetti OP. Preliminary investigation of respiratory self-gating for free-breathing segmented cine MRI. Magn Reson Med 2005; 53:159-168.
  17. Koktzoglou I, Simonetti OP, Li D. Coronary artery wall imaging: initial experience at 3 Tesla. J Magn Reson Imaging 2005; 21:128-132.
  18. Bi X, Li D. Coronary arteries at 3.0T: contrast-enhanced magnetization-prepared three-dimensional breath-hold MR angiography. J Magn Reson Imaging 2005; 21:133-139.
  19. So NMC, Lam WWM, Li D, Chan AKY, Sanderson JE, Metreweli C. Magnetic resonance coronary angiography with 3D TrueFISP: breath-hold versus respiratory gating. Br J Radiol 2005; 78:116-121.
  20. Omary RA, Schirf BE, Green JD, Kanwar YS, Shea SM, Carroll TJ, Carr JC, Li D. Catheter-directed MR angiography and cross-sectional imaging for the assessment of renal artery stenosis. J Vasc Interv Radiol 2005; 16:255-260.
  21. Zhang H, Shea S, Park V, Li D, Woodard PK, Gropler RJ, Zheng J. Accurate myocardial T1 measurements: toward quantification of myocardial blood flow with arterial spin labeling method. Magn Reson Med 2005; 53:1135-1142.
  22. Schirf BE, Green JD, Sato K, Larson AC, Shaibani A Salem R, Li D, Omary RA. Determination of optimal gadolinium concentration using SSFP for catheter-directed contrast-enhanced coronary MR angiography. Acad Radiol 2005; 12:771-775.
  23. Bi X, Park J, Li D. Contrast-enhanced 4D radial coronary artery imaging at 3T within a single breath-hold. Magn Reson Med 2005; 54:470-475.
  24. Shea SM, Fieno DS, Schirf BE, Omary RA, Li D. T2-prepared steady-state free precession (SSFP) blood oxygen level dependent (BOLD) MRI of myocardial perfusion in a dog stenosis model. Radiology 2005; 236:503-509.
  25. Bi X, Deshpande V, Simonetti O, Laub G, Li D. Three-dimensional breathhold SSFP coronary MRA: A comparison between 1.5T and 3.0T. J Magn Reson Imaging 2005; 22:206-212.
  26. Green JD, Omary, RA, Schirf BE, Tang R, Carr JC, Li D. Three-dimensional contrast-enhanced steady-state free precession for improved catheter-directed coronary artery magnetic resonance angiography. J Magn Reson Imaging 2005; 22:415-419.
  27. Zheng J, Li, D, Maggioni F, Abendschein D, Simonetti O, Laub G, Finn JP, Gropler RJ, Cavagna, FM. Single session magnetic resonance coronary angiography and myocardial perfusion imaging using the new blood pool compound B-22956 (Gadocoletic Acid): initial experience in a porcine model of coronary artery disease. Invest Radiol 2005; 40:604-613.
  28. Park J, Larson AC, Zhang Q, Simonetti O, Li D. 4D radial coronary artery imaging within a single breath-hold: cine angiography with phase sensitive fat suppression (CAPS). Magn Reson Med 2005; 54: 833-840.
  29. So NMC, Lam WWM, Li D, Chan AKY, Sanderson JE, Metreweli C. MR angiography of coronary arteries with a three dimensional magnetization-prepared true fast imaging with steady state procession sequence compared with conventional coronary angiography. Am Heart J 2005; 150:530-535.
  30. Park J, Larson AC, Zhang Q, Simonetti O, Li D. High-resolution steady-state free precession coronary magnetic resonance angiography within a single breath-hold: parallel imaging with extended cardiac data acquisition. Magn Reson Med 2005; 54:1100-1106.
  31. Green JD, Omary, RA, Schirf BE, Tang R, Lu B, Gehl JA, Huang JJ, Carr JC, Pereles FS, Li D. Comparison of x-ray fluoroscopy and interventional MRI for the assessment of coronary artery stenoses in swine. Magn Reson Med 2005; 54:1094-1099.
  32. Rhee TK, Larson AC, Prasad PV, Santos E, Sato KT, Salem R, Deng J, Paunesku T, Woloschak GE, Mulcahy MF, Li D, Omary RA. Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits. J Vasc Interv Radiol 2005; 16:1523-1528.
  33. Deshpande VS, Cavagna F, Maggioni F, Schirf BE, Omary RA, Li D. Comparison of gradient-echo and steady-state free precession for coronary artery magnetic resonance angiography using a gadolinium based intravascular contrast agent. Invest Radiol 2006; 41:292-298.
  34. Koktzoglou I, Harris KR, Tang R, Kane BJ, Misselwitz B, Weinmann HJ, Lv B, Nagaraj A, Roth SI, Carroll TJ, McPherson DD, Li D. Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine. Invest Radiol 2006; 41:299-304.
  35. Omary RA, Gehl JA, Schirf BE, Green JD, Lu B, Pereles FS, Huang J, Larson AC, Li D. MR imaging-versus conventional X-ray fluoroscopy-guided renal angioplasty in swine: prospective randomized comparison. Radiology 2006; 238:489-496.
  36. Koktzoglou I, Chung YC, Mani V, Carroll TJ, Morasch MD, Mizsei G, Simonetti OP, Fayad ZA, Li D. Multi-slice dark-blood carotid artery wall imaging: 1.5T and 3.0T comparison. J Magn Reson Imaging 2006; 23:699-705.
  37. Welker M, Salanitri J, Deshpande VS, Shea SM, Li D, Pereles FS. Coronary artery anomalies diagnosed by magnetic resonance angiography. Australas Radiol 2006; 50:114-121.
  38. Larson AC, Rhee TK, Deng J, Wang D, Sato KT, Salem R, Paunesku T, Woloschak G, Mulcahy MF, Li D, Omary RA. Comparison between intravenous and intraarterial contrast injection for dynamic 3D MRI of liver tumors in the VX2 rabbit model. J Magn Reson Imaging 2006, 24:242-247.
  39. Yang CW, Carr JC, Francois CJ, Shea SM, Deshpande VS, Meyers SN, Beohar N, Finn JP, Li D. Coronary magnetic resonance angiography using magnetization-prepared contrast-enhanced breath-hold volume-targeted imaging (MPCE-VCATS). Invest Radiol 2006; 41:639-644.
  40. Dharmakumar R, Koktzoglou I, Li D. Generating positive contrast from off-resonant spins with steady-state free precession magnetic resonance imaging: theory and proof-of-principle experiments. Phys Med Biol 2006; 51:4201-4215.
  41. Bi X, Deshpande V, Carr JC, Li D. Coronary artery magnetic resonance angiography (MRA): a comparison between the whole-heart and volume-targeted methods using a T2-prepared SSFP sequence. J Cardiovasc Magn Reson 2006; 8:703-707.
  42. Koktzoglou I, Chung YC, Carroll TJ, Morasch MD, Simonetti OP, Li D. Three-dimensional dark-blood SSFP for carotid artery wall imaging. Radiology, in press.

Graduate Students

Vibhas Deshpande
Steven Shea
Jordin Green
Andy Larson
Xiaoming Bi
Jaeseok Park
Ioannis Koktzoglo
Mark Crowe


Student awards

Steven Shea, Young Investigator Award, 6th Annual Society of Cardiovascular MR Scientific Sessions, Miami, Florida, Feb, 2003.