Biomedical Engineering

Guillermo A. Ameer

Professor of Biomedical Engineering

Education

D.Sc. Chemical Engineering
MIT, Cambridge, MA

B.S Chemical Engineering (Hons)
University of Texas, Austin, TX

A.S. Fluent in Spanish
Collin County Community College

Research Interests

Bio-artificial organ systems; cell delivery and transplantation; tissue engineering

Significant Recognition

• Northwestern University Drew Senyei, MD Translational Research Award, 2006
• American Heart Association Established Investigator Award, 2006
• National Science Foundation CAREER Award: Biodegradable elastomeric composite scaffolds for ligament reconstruction, 2006
• Illinois Institute of Regenerative Medicine: Stem cell-based vascular tissue engineering Award, 2006
• Wallace H. Coulter Early Career Translational Research Award, 2005

Selected Publications

1. Low pressure foaming: a novel method for the fabrication of porous scaffolds for tissue engineering. E.J. Chung, M.J. Sugimoto, J. Koh and G.A. Ameer . Tissue Engineering Part C: Methods, In Press
2. Polymer-based nitric oxide therapies: Recent insights in biomedical applications. Feature Article. M. Jen, M.C. Serrano, R. van Lith and G.A. Ameer . Advanced Functional Materials, In Press
3. The role of hydroxyapatite in citric acid-based nanocomposites: surface characteristics, degradation, and osteogenicity in vitro . E.J. Chung, M.J. Sugimoto and G.A. Ameer . Acta Biomaterialia, In Press
4. Antioxidants modulate the antiproliferative effects of nitric oxide on vascular smooth muscle cells and adventitial fibroblasts by regulating oxidative stress. E.K. Gregory, A.K. Vavra, E.S. Moreira, G.E. Havelka, Q. Jiang, V.R. Lee, R. Van Lith, G.A. Ameer, and M. R. Kibbe. American Journal of Surgery, In Press
5. Long-term in vivo response to citric acid-based nanocomposites for orthopaedic tissue engineering . E.J. Chung, P. Kodali, W. Laskin, J.L. Koh and G.A. Ameer . J Mater Sci Mater Med, 22 (9), pp 2131-2138, 2011
6. Novel biodegradable shape memory elastomers with drug releasing capabilities . Frontispiece Featured Article , M. Concepcion Serrano, L. Carbajal, and G.A. Ameer . Advanced Materials, , 23 (19), pp 2211-2215, 2011
7. Poly(diol-co-citrates) as novel elastomeric perivascular wraps for the reduction of neointimal hyperplasia. Serrano MC, Vavra AK, Jen M, Hogg ME, Murar J, Martinez J, Keefer LK, Ameer GA , Kibbe MR. Macromolecular Bioscience, 11(5), pp 700-709, 2011
8. Biohybrid strategies for vascular grafts. R. van Lith and Guillermo A. Ameer . In Tissue Engineering: From Lab to Clinic , Norbert Pallua and Christopher V. Suschek, editors, Springer, pp 279-316, 2011
9. Early tissue response to citric acid-based micro- and nanocomposites. E.J. Chung, H.J. Qiu, P. Kodali, S. Yang, S.M. Sprague, J. Hwong,J. Koh and G.A. Ameer . Journal of Biomedical Materials Research Part A,96A(1), pp 29-37,2011
10. Effect of bilateral oophorectomy on wound healing of the rabbit vagina .
    Yoram Abramov, Antonio R. Webb, Sylvia M. Botros, Roger P. Goldberg, Guillermo A. Ameer , Peter K. Sand. Fertility and Sterility, 95(4), pp 1467-1470, 2011
11. Urinary bladder smooth muscle regeneration utilizing bone marrow derived mesenchymal stem cell seeded elastomeric poly(1,8-octanediol-co-citrate) based thin films.Arun K. Sharmaa, Partha V. Hotaa, Derek J. Matokaa, Natalie J. Fullera, Danny Jandalia, Hatim Thakera, G.A. Ameer and Earl Y. Cheng. Biomaterials,31(24), pp 6207-6217, 2010
12. Advances and Applications of Biodegradable Elastomers in Regenerative Medicine Featured Article . M.C. Serrano, E.J. Chung,G.A. Ameer . Advanced Functional Materials, Volume 20 Issue 2, pp 192-208, 2010
13. Toward Engineering a Human Neoendothelium with Circulating Progenitor Cells. J. Allen, S. Khan, K.A. Lapidos, G.A. Ameer . Stem Cells,28(2), pp 318-328, 2010
14. Biodegradable nitric oxide-releasing poly(diol citrate) elastomers. H. Zhao, M.C. Serrano, D.A. Popowich, M.R. Kibbe,G.A. Ameer . Journal of Biomedical Materials Research Part A, Volume 93A, Issue 1, Pages 356-363, 2010
15. Citric acid-based elastomers provide a biocompatible interface for vascular grafts . M.R. Kibbe, J. Martinez, D.A. Popowich, M.R. Kapadia, S.S. Ahanchi, O.O. Aalami, Q. Jiang, A.R. Webb, J. Yang, T. Carroll, G.A. Ameer . Journal of Biomedical Materials Research Part A, Volume 93A, Issue 1, Pages 314-324, 2010
16. Sustained transgene expression via citric acid-based polyester elastomers.Zhang XQ, Tang H, Hoshi R, De Laporte L, Qiu H, Xu X, Shea LD, Ameer GA . Biomaterials, vol 30, pp 2632-41, 2009
17. Nanoporous biodegradable elastomers. Inside Cover Art . R. Hoshi, S. Behl, and G.A. Ameer . Advanced Materials,vol 21, pp 188-192, 2009
18. Modulating the mechanical properties of poly(diol citrates) via the incorporation of a second type of crosslink network. H. Zhao and G.A. Ameer. Journal of Applied Polymer Science ,114(3), pp 1464-1470, 2009
19. Role of nanocomposites in bone regeneration . Cover and Featured Article . M. Rogel, H. Qiu, and G.A. Ameer . Journal of Mat. Chem ., vol 18, pp4233 4241, 2008
20. Characterization of porcine circulating progenitor cells: Towards a functional endothelium . J. Allen, S. Khan, M. Concepcion-Serrano, and G.A. Ameer . Tissue Engineering, vol 14, pp 183-194, 2008.
21. A new strategy to characterize the extent of reaction of thermoset elastomers . A. Webb, J. Yang, G.A. Ameer . Journal of Polymer Science Part A: Polymer Chemistry, vol 46 pp 1318-1328, 2008
22. Endothelial cells derived from circulating progenitors as an effective source to functional endothelialization of NaOH-treated poly(epsilon-caprolactone) films. Serrano MC, Pagani R, Ameer GA , Vallet-Regi M, Portoles MT. Journal of Biomedical Materials Research: Part A., vol 87 pp 964-971, 2008.
23. In vitro characterization of a compliant biodegradable scaffold with a novel bioreactor system . A. Webb, B.D. Macrie, A.S. Ray, J.E. Russo, A.M. Siegel, M. Glucksberg, and G.A. Ameer . Annals of Biomed Eng., Vol 35, pp 1357-1367, 2007.
24. A biodegradable vascularizing membrane: A feasibility study . A. Kaushiva, V. Turzhitsky, M. Darmoc, V. Backman and G.A. Ameer . Acta Biomaterialia, vol 3, pp 631-642, 2007.
25. Biodegradable poly(diol citrate) nanocomposite elastomers for soft tissue engineering. A. Webb, V. Kumar, and G.A. Ameer . Journal of Materials Chemistry, vol 17, pp 900 906, 2007
26. Hemocompatibility evaluation of poly(1,8 octanediol citrate) in vitro for vascular tissue engineering . D. Motlagh, J. Allen, J.Yang, R. Hoshi, K.Y. Liu, and G.A. Ameer . Journal of Biomedical Materials Research: Part A, vol 82, pp 907-916, 2007.
27. Spectroscopic translation of cell-material interactions . J. Allen, Y. Liu, Y. Kim, V. Turzhitsky, V. Backman and G.A. Ameer . Biomaterials, vol 28, pp 162-174, 2007.
28. Engineering sub-100 nm multilayer nanoshells . X. Xia, Y. Liu, V. Backman and G.A.Ameer .Nanotechnology, vol 17, pp 5435-5440, 2006.
29. A citric acid-based poly(diol citrate)-hydroxyapatite composite for orthopedic implants. H. Qiu, J. Yang, P Kodali, J. Koh, and G.A. Ameer .Biomaterials, vol 27, pp 5845-5854, 2006.
30. Mechanical interlocking of engineered cartilage to an underlying polymeric substrate: Towards a biohybrid cartilage tissue equivalent . L. Romito and G.A. Ameer . Annals of Biomed. Eng., vol 34, pp 737-747, 2006.
31. Modulating ePTFE vascular graft host response via citric acid-based biodegradable elastomers . J. Yang, D. Motlagh, J. Allen, A. Webb, M. Kibbe, O. Aalami, M. Kapadia, T. Carroll, and G.A. Ameer .Advanced Materials, vol 18, 1493-1498, 2006.
32. Hemocompatibility evaluation of poly(glycerol-sebacate) in vitro for vascular tissue engineering. D. Motlagh, J. Yang, K.Y. Lui, A. Webb, and G.A. Ameer . Biomaterials, vol 27, pp 4315-4324, 2006.
33. A new biodegradable polyester elastomer for cartilage tissue engineering. Y. Kang, J. Yang, S. Khan, L. Anissian, and G.A. Ameer .Journal of Biomedical Materials Research: Part A. vol 77A pp331-339, 2006.
34. Synthesis and evaluation of novel biodegradable elastomeric polyesters, J. Yang, A. Webb, S. Pickerill, G. Hageman and G.A. Ameer . Biomaterials, vol 27, pp 1889-1898, 2006 .
35. Biomechanical properties of vaginal versus abdominal surgical wound healing in a rabbit model. Y. Abramov, A. Webb, J. Miller, A. Alshahrour, S. Botros, R. Goldberg, G.A. Ameer and P. Sand. Am J Obstet Gynecol., vol 194, pp 1472-1477, 2006.
36. A novel biphasic elastomeric scaffold for small-diameter blood vessel tissue engineering. J. Yang, D. Motlagh, A. Webb and G.A. Ameer .Tissue Engineering, vol 11, pp 1876-1886, 2005.
37. Assessment of the stability of an immunoadsorbent for the removal of b2microglobulin from blood. C. Daniels, E. Woolverton, S. Sprague, and G.A. Ameer . Blood Purification, vol 23 pp 287-297, 2005
38. Optimal design of structured nanospheres for ultra sharp light scattering resonances as molecular imaging multilabels. K. Chen, Y. Liu, G.A. Ameer , and V. Backman. Journal of Biomedical Optics, 10(2), 024005, 1-6 (2005).
39. Biodegradable Polyester Elastomers in Tissue Engineering. A. Webb, J. Yang, and G.A. Ameer . Expert Opinion on Biological Therapy, vol 4, no. 6, pp 801 - 812, 2004.
40. Novel citric acid-based biodegradable elastomers for tissue engineering. J. Yang, A. Webb, and G.A. Ameer . Advanced Materials, vol 16, pp 511-516, 2004.
41. Single-Chain Antibody Fragment-Based Adsorbent for the Extracorporeal Removal of microglobulin from Blood. E.A. Grovender, B. Kellogg, Singh, Blom, Ploegh, D. Wittrup, R. Langer and G.A. Ameer . Kidney International, vol 65 pp 310-322, 2004 .
42. A Tough Biodegradable Elastomer. Y. Wang, G.A. Ameer , B.J. Sheppard, and R. Langer. Nature Biotechnology, vol 20(6), pp 587-591, 2002.
43. A Biodegradable Composite Scaffold for Cell Transplantation. G.A. Ameer , T.A. Mahmood, and R. Langer. Journal of Orthopaedic Research, vol 20(1), pp 16-19, 2002.
44. Immunoadsorption Model for a Fluidized-Bed Blood Detoxification Device. E.A. Grovender, C.L. Cooney, R. Langer, and G.A. Ameer . AIChE Journal, vol 48(10) pp 2357-2365, 2002
45. A Novel Immunoadsorption Device for Removing b2microglobulin from Whole Blood. G.A. Ameer , E.A. Grovender, D. Ting, H. Ploegh, W. Owen, M. Rupnik, and R. Langer. Kidney International, vol 59, pp 1544-1550, 2001.
46. Modalities for the Removal of b2microglobulin from Blood. G.A. Ameer . Seminars in Dialysis, vol. 14(2), pp 103-106, 2001.
47. Cell-killing Potential of a Water-Soluble Radical Initiator. G.A. Ameer , E.T. Crumpler, and R.Langer. International Journal of Cancer, vol 93(6), pp 875-879, 2001.
48. Modeling the Mixing Behaviour of a Novel Fluidized Extracorporeal Immunoadsorber. E.A. Grovender, C.L. Cooney, R. Langer and G.A. Ameer . Chemical Engineering Science, 56(18), pp 5437-5441, 2001.
49. Regional heparinization via simultaneous separation and reaction in a novel Taylor-Couette flow device. Ameer GA , Raghavan S, Sasisekharan R, Harmon W, Cooney CL, Langer R.Biotechnol Bioeng., 63(5), pp618-24, 1999.
50. Investigation of a whole blood fluidized bed Taylor-Couette flow device for enzymatic heparin neutralization. Ameer GA , Harmon W, Sasisekharan R, Langer RBiotechnol Bioeng., 62(5), pp602-8, 1999.
51. Ex Vivo Evaluation of a Taylor-Couette Flow, Immobilized Heparinase I Device for Clinical Application. G.A. Ameer , G. Barabino, R. Sasisekharan, C.L. Cooney, W. Harmon, and R. Langer. Proceedings of the National Academy of Sciences, USA, vol. 96, pp 2350-2355, 1999.

Patents

• Transdermal Thermal Polymerization (U.S. patent #7,097,855 issued 08-2006) G.A. Ameer, E.T. Crumpler, and R. Langer
• Multidimensional Elastic Light Scattering (Application #11/261,452) V. Backman, H. Roy, R. Wali, Y. Kim , Y. Liu, J. Yang , J. Allen, A. Webb, and G.A. Ameer.
• Apparatus for Treating Whole Blood (U.S. Patent #6099730 issued 08-2000) G. A. Ameer , R. Langer, M. Rupnik, H. Ploegh, and E. Grovender.
• Cell Delivery Using Controllable Degradable Mesh-Gel Constructs (U.S. Patent #6699470 issued 03-2004) G. A. Ameer and R. Langer.
• Biodegradable Polymer (Application # 601340432, US and International, pending) Y. Wang, G. A. Ameer, and R. Langer
• Biodegradable Elastomers for Tissue Engineering (Pending) J. Yang, A. Webb, and G.A. Ameer.
• Functionalizing Medical Implants: A Tissue Engineering Approach (Pending) J. Yang and G.A. Ameer.
• A Novel(diol-co-citrate) Hydroxyapatite Composite for Clinical Fixation Devices (Pending) ,J. Yang, H. Qiu, and G.A. Ameer.
• Receptor-Based Blood Detoxification System (Pending) C. Daniels, S. Sprague, and G.A. Ameer.