Timothy Carroll
Associate Professor of Biomedical Engineering and Radiology
Research Interests
The role of Magnetic Resonance Imaging (MRI) in day-to-day clinical practice is growing. Gadolinium-based contrast agents have traditionally been used to enhance the signal from flowing blood allowing rapid acquisition of high spatial resolution angiograms for the diagnosis of vascular disease. The ability to view the anatomy in 3D as well as the minimally invasive nature of MRI image acquisitions offer some advantages over more invasive X-ray angiography. My research has been focused on the development of MR k-space sampling and image reconstruction strategies for acquisition of high spatial resolution time-resolved MR angiograms. The ability of time-resolved 3D angiography to depict compromised flow has proven a valuable tools in assessing the severity of vascular disease, a major source of morality and morbidity in industrialized nations.
Recently, developments in contrast-enhanced MR image acquisitions and data analysis are providing a larger range of options for the diagnosis of ischemic stroke and certain types of cancer. I'm currently working with indicator dilution techniques applied to heavily T2-weighted images for the assessment of cerebral perfusion. These imaging techniques have the potential to allow for rapid, real-time assessment of cerebral blood flow for the triage of patients suffering from acute stroke. In addition, I am using pharmocokinetic models applied to contrast-enhanced, time-resolved T1-weighted uptake curves in tumors to assess vascular volume, blood vessel permeability. These imaging techniques have the potential potential for the staging, and tracking the response to therapy of certain types of cancer.
Conferences
XV International Meeting of the MR Angiography Club Dublin, Ireland Sept 24-26.
Abstract Titles
- High Resolution Time-Resolved Pulmonary MRA Using TRICKS with Ultra-short Repetition Times
- Contrast-enhanced MR angiography of the circle of Willis at 3 Tesla
- Contrast-enhanced MR angiography (CE-MRA) using a projection-onto-convex-sets (POCS) reconstruction algorithm
Significant Recognition
- Whitaker Foundation (RG-03-006). "Determination of pulmonary blood volume in heart failure with contrast-enhanced magnetic resonance imaging" Award $231,466.00
Selected Publications
- Carroll, T. J.; Carr, J. C., “Magnetic Resonance Angiography: Principles and Applications”, , (2012)
- Carroll, T. J.; others; Shin, W.; Mouannes, J. J., “MRI method for quantification of cerebral perfusion”, , (2012)
- Carroll, T. J.; Francis, P. L.; O'Connor, P.; Zhang, L.; Eilaghi, A., “Decreased Frontal Lobe Gray Matter Perfusion in Cognitively Impaired Patients with Secondary-Progressive Multiple Sclerosis Detected by the Bookend Technique”, American Journal of Neuroradiology, (2012)
- Carroll, T. J.; Francis, P. L.; Jakubovic, R.; O'Connor, P.; Zhang, L., “Robust Perfusion Deficits in Cognitively Impaired Patients with Secondary-Progressive Multiple Sclerosis”, American Journal of Neuroradiology, (2012)
- P. Vakil, S. A. Ansari, M. C. Hurley, H. Bhat, H. H. Batjer, B. R. Bendok, C. S. Eddleman and T. J. Carroll, “Magnetization spoiling in radial FLASH contrast-enhanced MR digital subtraction angiography”, Journal of Magnetic Resonance Imaging, (2012)
- P. Vakil, J. C. Carr and T. J. Carroll, “Combined renal MRA and perfusion with a single dose of contrast”, Magnetic Resonance Imaging, (2012)
- Carroll, T. J.; Lee, G. R.; Seiberlich, N.; Sunshine, J. L.; Griswold, M. A., “Rapid time-resolved magnetic resonance angiography via a multiecho radial trajectory and GraDeS reconstruction”, Magnetic Resonance in Medicine, (2012)
- J. J. Mouannes-Srour, W. Shin, S. A. Ansari, M. C. Hurley, P. Vakil, B. R. Bendok, J. L. Lee, C. P. Derdeyn and T. J. Carroll, “Correction for arterial-tissue delay and dispersion in absolute quantitative cerebral perfusion DSC MR imaging”, Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, (2012)
