Affiliated Faculty Profile

Thomas J. Meade

Websites:
Meade Research Group

Research Interest:

The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.

Selected Publications:

121. Sukerkar P, MacRenaris KW, Meade TJ, Burdette JA. A Steroid-Conjugated Magnetic Resonance Probe Enhances Contrast in Progesterone Receptor Expressing Organs and Tumors In Vivo, Molecular Pharmaceutics, in press.

120. Schultz-Sikma, EA., Meade TJ., "Supramolecular Chemistry in Biological Imaging In Vivo," In Supramolecular Chemistry: From Molecules to Nanomaterials; P. A. Gale and J. W. Steed, Eds.; John Wiley & Sons, Ltd., 2011, in press.

119. Schultz-Sikma EA, Joshi, HM, Ma, Q, Macrenaris KW, Eckermann AL, Dravid VP, Meade TJ, Probing the Chemical Stability of Mixed Ferrites: Implications for MR Contrast Agent Design, Chemistry of Materials, 2011, 23(10), 2657-2664. PMC Journal - In Process.

118. Song Y, Meade TJ, Astashkin AV, Klein EL, Enemark JH, Raitsimring A. Pulsed Dipolar Spectroscopy Distance Measurements in Biomacromolecules Labeled with Gd(III) Markers, Journal of Magnetic Resonance, 2011, 210(1), 59-68. PMC Journal - In Process.

117. Mastarone DJ, Harrison VSR, Eckermann AL, Parigi G, Luchinat C, Meade TJ, A Modular System for the Synthesis of Multiplexed Magnetic Resonance Probes, American Chemical Society, 2011, 133(14), 5329-5337. PMC Journal - In Process.

116. Karfeld-Sulzer L, Waters EA, Kohlmeir EK, Kissler H, Zhang X, Kaufman DB, Barron AE, Meade TJ. Protein Polymer MRI Contrast Agents: Longitudinal Analysis of Biomaterials in Vivo. Magnetic Resonance in Medicine, 2011, 65(1) 200-8. PMCID: PMC2995002.

115. Sukerkar P, Rezvi U, MacRenaris K, Patel P, Wood J, Meade TJ. Polystyrene Microsphere-Ferritin Conjugates: A Robust Phantom for Correlation of Relaxivity and Size Distribution. Magnetic Resonance in Medicine, 2011, 65(2), 522-30. PMC Journal - In Process.

114. Ahrens MJ, Bertin PA, Gaustad AG, Georganopoulou D, Wunder M, Blackburn GF, Gray HB, Meade TJ. Spectroscopic and redox properties of amine-functionalized K2[OsII(bpy)(CN)4] complexes. Dalton Transactions (2011), 40(8), 1732-1736.

113. Potapov A, Song Y, Meade TJ, Goldfarb D, Astashki AV. Distance measurements in model Bis-Gd(III) complexes with flexible "bridge": Emulation of biological molecules having flexible structure with Gd(III) label attached, Journal of Magnetic Resonance, 2010, 205(1), 38-49. PMCID: PMC2885582.

112. Lee, S, Song Y, Hong BJ, MacRenaris KW, Mastarone DJ, O'Halloran TV, Meade TJ, Nguyen ST. Modular Polymer-Caged Nanobins as a Theranostic Platform with Enhanced Magnetic Resonance Relaxivity and pH-Responsive Drug Release. Angewandte Chemie, International Edition (2010), 49(51), 9960-9964 PMC Journal - In Process.

111. Hu F, Joshi HM, Dravid VP, Meade TJ. High-performance nanostructured MR contrast probes. Nanoscale (2010), 2(10), 1884-1891. PMCID: PMC3110061.

110. Song Y, Zong H, Trivedi ER, Vesper BJ, Waters EA, Barrett AGM, Radosevich JA, Hoffman BM, Meade TJ,. Synthesis and Characterization of New Porphyrazine-Gd(III) Conjugates as Multimodal MR Contrast Agents. Bioconjugate Chemistry (2010), 21(12), 2267-2275. PMCID: PMC3075316.

109. Bertin, PA., Ahrens MJ, Bhavsar, K, Georganopoulou D, Wunder M, Blackburn GF, Meade TJ, Ferrocene and Maleimide-Functionalized Disulfide Scaffolds for Self-Assembled Monolayers on Gold. Organic Letters (2010), 12(15), 3372-3375.

108. Eckermann AL, Feld DJ, Shaw JA, Meade TJ. Electrochemistry of Redox-Active Self Assembled Monolayers, Coord. Chem Rev., 2010, 254(15-16), 1769-1802. PMCID: PMC2885823.

107. Karfeld-Sulzer L, Waters E, Davis N, Meade TJ, Barron A. Multivalent Protein Polymer MRI Contrast Agents: Controlling Relaxivity via Modulation of Amino Acid Sequence, Biomacromolecules, 2010, 11(6), 1429-1436. PMCID: PMC2995002.

106. Harney AS, Meade TJ. Molecular imaging of in vivo gene expression. Future Medicinal Chemistry, 2010, 2(3), 503-519.

105. Trivedi ER, Harney AS, Olive MB, Podgorski I, Moin K, Sloane BF, Barrett AGM, Meade TJ, Hoffman BM. Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor accumulation. PNAS, 2010, 107(4), 1284-1288. PMCID: PMC2824358.

104. Manus L, Mastarone D, Waters EA, Zhang X, Schultz-Sikma E, MacRenaris K, Ho D, Meade TJ. Gd(III)-nanodiamond conjugates for MRI contrast enhancement. Nano Letters, 2010, 10(2), 484-489. PMCID: PMC2829273.

103. Hu F, MacRenaris K, Waters EA, Schultz-Sikma EA, Eckermann AL, Meade TJ. Highly Dispersible, Superparamagnetic Magnetite Nanoflowers for Magnetic Resonance Imaging. Chem. Comm., 2010, 46(1), 73-75. PMC Journal - In Process

102. Ho D, Meade TJ, Gd(III)-Nanodiamond Conjugates for MRI Contrast Enhancement. Nano Letters, 2010, 10(2), 484-489.

101. Eckermann AL, Shaw J, Meade TJ. Kinetic Dispersion in Redox Active Dithiocarbamate Monolayers. Langmuir, 2010, 26(4), 2904-2913. PMC Journal - In Process.

100. Trivedi ER, Harney AS, Olive MB, Podgorski I, Moin K, Sloane BF, Barrett AGM, Meade TJ, Hoffman BM. Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor accumulation. PNAS, Early Edition, 2009, (Dec. 23 2009) 1-5, 5 pp.

99. Hu F, MacRenaris K, Waters EA, Schultz-Sikma EA, Eckermann AL, Meade TJ. Highly Dispersible, Superparamagnetic Magnetite Nanoflowers for Magnetic Resonance Imaging. Chem. Comm., 2010, 46(1), 73-75. PMC Journal - In Process.

98. Manus, LM, Mastarone, DJ, Waters, Zhang. XQ, Schultz-Sikma, EA, MacRenaris, K, Ho D, Meade TJ, Gd(III)-Nanodiamond Conjugates for MRI Contrast Enhancement. Nano Letters, 2010, 10(2), 484-489.

97. Eckermann AL, Shaw J, Meade TJ. Kinetic Dispersion in Redox Active Dithiocarbamate Monolayers. Langmuir, 2010, 26(4), 2904-2913. PMC Journal - In Process.