Biomedical Engineering

Milan Mrksich

Henry Wade Rogers Professor in Biomedical Engineering, Chemistry and Cell and Molecular Biology

Education

Ph.D. Chemical Biology, Caltech

B.S. Chemistry, University of Illinois

Research Interests

Biomaterials and interfaces; cell adhesion and migration; electroactive interfaces; physical organic chemistry of interfacial reactions; bio-inspired nanostructured materials; biochips

Selected Publications

1. Modular Assembly of Protein Building Blocks to Create Precisely-Defined MegaMolecules.  J.A. Modica, S. Skarpathiotis and M. Mrksich.  ChemBioChem, 2012, 13, 2331-2334.
2. The Mechano-Stability of Isolated Focal Adhesions is Strongly Dependent on pH.  K.G. Beaumont and M. Mrksich.  Chem. & Biol., 2012, 19, 711-720. 
3. Directing Stem Cell Fate by Controlling the Affinity and Density of Ligand-Receptor Interactions at the Biomaterials Interface.  K.A. Kilian and M. Mrksich.  Ang. Chem. Int. Ed.,2012, 51, 4891-4895. 
4. Three-Component Reaction Discovery Enabled by SAMDI Mass Spectrometry.  T.J. Montavon, J. Li, J.R. Cabrera-Pardo, M. Mrksich and S.A. Kozmin.  Nature Chemistry, 2012, 4, 45-51.  
5. Discovery of Glycosyltransferases Using Carbohydrate Arrays and Mass Spectrometry.  L. Ban, N. Pettit, L. Li, A.D. Stuparu, L. Cai, W. Chen, W. Guan, P.W. Wang and M. Mrksich.  Nat. Chem. Biol., 2012, 8, 769-773. 
6. The RGD and FEI Motifs in Nephronectin Bind to Different Sites in Integrin α8β1.  J. Sánchez-Cortés and M. Mrksich.  ACS Chem. Biol., 2011, 6, 1078-1086. 
7. High-Throughput Screening of Small Molecule Libraries using SAMDI Mass Spectrometry.  Z.A. Gurard-Levin, M.D. Scholle, A.H. Eisenberg and M. Mrksich.  ACS Combinatorial Chemistry, 2011, 13, 347-350. 
8. De Novo Motif for Kinase Mediated Signaling Across the Cell Membrane.  R.T. Petty and M. Mrksich.  Integrative Biology, 2011, 3, 816-822. 
9. Using Peptide Arrays and Mass Spectrometry to Develop Selective Substrates for Members of the Lysine Deacetylase Family.  Z. Gurard-Levin, K. Kilian, J. Kim, K. Bähr and M. Mrksich.  ACS Chem. Biol., 2010, 5, 863-873. 
10. Geometric Cues for Directing the Differentiation of Mesenchymal Stem Cells.  K.A. Kilian, B. Bugarija, B.T. Lahn and M. Mrksich.  Proc. Natl. Acad. Sci., USA, 2010, 107, 4872-4877.